Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Diffusion01:12

Diffusion

219.9K
Diffusion is the passive movement of substances down their concentration gradients—requiring no expenditure of cellular energy. Substances, such as molecules or ions, diffuse from an area of high concentration to an area of low concentration in the cytosol or across membranes. Eventually, the concentration will even out, with the substance moving randomly but causing no net change in concentration. Such a state is called dynamic equilibrium, which is essential for maintaining overall...
219.9K
Diffusion01:21

Diffusion

6.4K
Diffusion is a type of passive transport. In passive transport, a substance tends to move from an area of high concentration to an area of low concentration until the concentration is equal across the space. For example, take the diffusion of substances through the air. When someone opens a perfume bottle in a room filled with people, the perfume is at its highest concentration in the bottle and is at its lowest at the edges of the room. The perfume vapor will diffuse, or spread away, from the...
6.4K
Facilitated Diffusion01:16

Facilitated Diffusion

1.3K
The plasma membrane, a critical structure in cellular biology, houses an array of transporters, or carrier proteins, interspersed within its lipid bilayer. These proteins play a crucial role in solute transport through facilitated diffusion, a form of passive diffusion that uses transporters to move the molecules across the membrane.
In this process, substrates such as organic compounds and ions interact with a transporter on one side, triggering conformational changes in proteins that enable...
1.3K
Behavior of Gas Molecules: Molecular Diffusion, Mean Free Path, and Effusion03:48

Behavior of Gas Molecules: Molecular Diffusion, Mean Free Path, and Effusion

31.4K
Although gaseous molecules travel at tremendous speeds (hundreds of meters per second), they collide with other gaseous molecules and travel in many different directions before reaching the desired target. At room temperature, a gaseous molecule will experience billions of collisions per second. The mean free path is the average distance a molecule travels between collisions. The mean free path increases with decreasing pressure; in general, the mean free path for a gaseous molecule will be...
31.4K
Protein Diffusion in the Membrane01:24

Protein Diffusion in the Membrane

5.7K
Proteins show rotational as well as lateral diffusion across the membrane. The lateral diffusion of proteins was confirmed through the cell fusion experiment where mouse and human cells were fused, resulting in hybrid cells. When the human and mouse cells fused, the specific membrane proteins on human and mouse cells were marked with the red and green-fluorescent markers, respectively. Initially, the red and green fluorescence was located on the respective hemisphere of the cell. As time...
5.7K
Assessment of Diffusion and Perfusion01:17

Assessment of Diffusion and Perfusion

1.7K
Understanding and evaluating diffusion and perfusion is critical in assessing a patient's respiratory and circulatory health. These processes play key roles in maintaining the body's internal environment, ensuring that tissues receive adequate oxygen while waste products are efficiently removed.
The Role of Diffusion in Respiration
Diffusion is the process by which molecules move from an area of higher concentration to an area of lower concentration. In the respiratory system, this...
1.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A Case of Synchronous Subcarinal Lymph Node Metastasis from Double Primary Cancers with Small Cell Lung Cancer and Prostate Cancer.

Internal medicine (Tokyo, Japan)·2026
Same author

Atopic Dermatitis During Ustekinumab Therapy in a Patient With Ulcerative Colitis: A Case Report and Review of Targeted Therapies in Coexisting Diseases.

Cureus·2026
Same author

Epstein-Barr virus reactivation as a potential underlying contributor to atypical features of microscopic polyangiitis.

Modern rheumatology case reports·2026
Same author

What Lies Beyond the Thyroid? A Case of Neck Pain, Fever, and Hypertension.

Journal of general and family medicine·2026
Same author

A case of Lynch syndrome diagnosed after nine metachronous cancers detected over 35 years.

Clinical journal of gastroenterology·2026
Same author

A Case of Remnant Cholecystitis with an Endoscopically Achieved Definitive Diagnosis.

Internal medicine (Tokyo, Japan)·2026

Related Experiment Video

Updated: Feb 7, 2026

Author Spotlight: Investigating the Pathophysiology of Eosinophilic Esophagitis
03:23

Author Spotlight: Investigating the Pathophysiology of Eosinophilic Esophagitis

Published on: May 10, 2024

1.4K

Atrophic dermatofibrosarcoma protuberans with diffuse eosinophilic infiltrate.

Noriyuki Hirashima1, Noriyuki Misago, Taro Shinogi

  • 1Division of Dermatology, Department of Internal Medicine, Faculty of Medicine, Saga University, Saga, Japan. hirashn@cc.saga-u.ac.jp

The Journal of Dermatology
|July 20, 2006
PubMed
Summary

This case report details an unusual presentation of atrophic dermatofibrosarcoma protuberans (DFSP), a skin cancer variant. The tumor exhibited significant eosinophilic infiltration, a feature not previously documented in DFSP.

More Related Videos

Digital Spatial Profiling for Characterization of the Microenvironment in Adult-Type Diffusely Infiltrating Glioma
09:17

Digital Spatial Profiling for Characterization of the Microenvironment in Adult-Type Diffusely Infiltrating Glioma

Published on: September 13, 2022

2.8K
Identification and Characterization of Immunogenic RNA Species in HDM Allergens that Modulate Eosinophilic Lung Inflammation
08:44

Identification and Characterization of Immunogenic RNA Species in HDM Allergens that Modulate Eosinophilic Lung Inflammation

Published on: May 30, 2020

6.6K

Related Experiment Videos

Last Updated: Feb 7, 2026

Author Spotlight: Investigating the Pathophysiology of Eosinophilic Esophagitis
03:23

Author Spotlight: Investigating the Pathophysiology of Eosinophilic Esophagitis

Published on: May 10, 2024

1.4K
Digital Spatial Profiling for Characterization of the Microenvironment in Adult-Type Diffusely Infiltrating Glioma
09:17

Digital Spatial Profiling for Characterization of the Microenvironment in Adult-Type Diffusely Infiltrating Glioma

Published on: September 13, 2022

2.8K
Identification and Characterization of Immunogenic RNA Species in HDM Allergens that Modulate Eosinophilic Lung Inflammation
08:44

Identification and Characterization of Immunogenic RNA Species in HDM Allergens that Modulate Eosinophilic Lung Inflammation

Published on: May 30, 2020

6.6K

Area of Science:

  • Dermatopathology
  • Oncology
  • Dermatology

Background:

  • Atrophic dermatofibrosarcoma protuberans (DFSP) is a clinical variant of DFSP, characterized by depressed skin lesions.
  • Dermatofibrosarcoma protuberans is a rare, locally aggressive skin cancer originating in the dermis.

Observation:

  • A 55-year-old woman presented with a depressed, dark-red epigastric lesion.
  • Histopathology revealed typical DFSP features: fibroblast proliferation, storiform pattern, and CD34 positivity.
  • The tumor tissue showed marked eosinophilic infiltration.

Findings:

  • Diagnosis of atrophic DFSP was confirmed based on clinical and histopathological findings.
  • The presence of significant eosinophilic infiltration in DFSP tissue is a novel observation.
  • This represents a potentially unique case of atrophic DFSP.

Implications:

  • This case expands the known histopathological spectrum of DFSP.
  • Further research may elucidate the role and significance of eosinophilic infiltration in DFSP.
  • Understanding rare variants like this improves diagnostic accuracy and patient management.