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Related Experiment Videos

Physiological studies of cortical spreading depression.

Justin M Smith1, Daniel P Bradley, Michael F James

  • 1Cambridge Centre for Brain Repair, University of Cambridge, E.D. Adrian Building, Robinson Way, Cambridge CB1 5RH, UK.

Biological Reviews of the Cambridge Philosophical Society
|July 20, 2006
PubMed
Summary

Cortical spreading depression (CSD) causes brain waves of neuronal activity and depression. MRI studies reveal CSD

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Area of Science:

  • Neuroscience
  • Neurophysiology
  • Cerebrovascular Physiology

Background:

  • Cortical spreading depression (CSD) involves waves of neuronal hyperexcitability and depression.
  • CSD is triggered by ion shifts, including potassium (K+) release.
  • Astrocytes play a role in CSD propagation through ion buffering and signaling.

Purpose of the Study:

  • To investigate changes in cerebral blood volume and apparent diffusion coefficient (ADC) during CSD using MRI.
  • To characterize the features of CSD events and their relationship to cerebral blood flow.
  • To explore the potential therapeutic effects of sumatriptan on CSD-related cerebrovascular changes.

Main Methods:

  • Magnetic resonance imaging (MRI), including diffusion-weighted echoplanar imaging.

Related Experiment Videos

  • Pixelwise analysis of ADC and T2*-weighted waveforms.
  • Administration of KCl stimulus to induce CSD.
  • Assessment of cerebrovascular changes and response to sumatriptan.

    • Main Results:

    • CSD induced measurable changes in ADC and cerebral blood volume.
    • ADC changes correlated inversely with T2*-weighted waveforms reflecting blood flow.
    • Prolonged decreases in cerebral blood flow were observed, which were blocked by sumatriptan.

    Conclusions:

    • MRI-based ADC mapping is a valuable tool for studying CSD dynamics.
    • CSD exhibits complex propagation patterns with primary and secondary events.
    • CSD phenomena may be relevant to human migraine aura and cerebrovascular conditions like ischemia.