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Published on: July 4, 2014
Transbuccal tablets of carbamazepine: formulation, release and absorption pattern
L I Giannola1, V De Caro, G Giandalia
1Department of Chemistry and Pharmaceutical Technologies, University of Palermo, Italy. litagian@unipa.it
Summary
Carbamazepine (CBZ) effectively penetrates buccal mucosa, demonstrating potential for transbuccal drug delivery. Novel tablet formulations offer prolonged drug release, enhancing buccal administration possibilities.
Area of Science:
- Pharmaceutical Sciences
- Drug Delivery Systems
Background:
- Transbuccal drug administration offers advantages over peroral delivery.
- Carbamazepine (CBZ) is a drug with potential for buccal delivery.
Purpose of the Study:
- To evaluate carbamazepine's penetration through buccal mucosa.
- To assess three tablet formulations for transbuccal drug release.
Main Methods:
- Carbamazepine permeation studied using Franz cells (porcine mucosa) and Transwell systems (RHO epithelium).
- Drug release rates evaluated from three tablet formulations: microspheres, matrices, and physical mixtures.
Main Results:
- Carbamazepine demonstrated significant penetration, with flux and permeability coefficients measured.
- Non-conventional tablet formulations, particularly loaded matrices, provided prolonged drug release.
- Loaded matrix tablets released CBZ faster than microsphere tablets.
Conclusions:
- Carbamazepine can effectively penetrate buccal mucosal membranes.
- Developed tablet formulations show promise for sustained transbuccal drug delivery of CBZ.
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