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Updated: Aug 7, 2026
Biological Compatibility Profile on Biomaterials for Bone Regeneration
Published on: November 16, 2018
Study of biological safety of scaffold material with heterologous deproteinized bone
Lei Liu1, Kang-lai Tang, Liu Yang
1Center for Joint Surgery, Southwest Hospital, Third Military Medical University, Chongqing, 400038, China.
Objective:
To evaluate the biological safety of manufactured heterologous deproteinized bone and to provide an experimental basis for clinical applications.
Methods:
Deproteinized bone (10 mm) and leaching liquor were made from pig ribs with a series of physical and chemical methods, then were evaluated through acute and subacute toxicity test, hemolysis test, pyrogen test, intracutaneous test, intramuscular implantation test and cytotoxity test.
Results:
No obvious toxicity, hemolysis, pyrogenic characteristics, skin irritation, inflammatory reaction after intramuscular implantation and cytotoxity were observed.
Conclusions:
The heterologous deproteinized bone has good biological safety and meets all the demands of scaffold material for tissue engineering.
