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Published on: January 14, 2014
Recurrent cytogenetic aberrations in histologically benign, invasive meningiomas of the sphenoid region
Andrey Korshunov1, Vasiliy Cherekaev, Ali Bekyashev
1Department of Neuropathology, N.N. Burdenko Neurosurgical Institute, 4-th Tverskaya-Yamskaya str. 16, Fadeeva str. 5, Moscow, 125047, Russia. akorshunov@nsi.ru
Abstract:
Meningiomas that arise in the sphenoid region (MSR) often display growth patterns leading to widespread invasion and destruction of the surrounding structures. Consequently, there is still estimated recurrence rate up to 30% with MSR. Conventional cytogenetic studies have failed to reveal aberrations characteristic of invasive meningiomas. Here we investigated 10 invasive and 5 non-invasive MSR using the array-based comparative genomic hybridization (array-CGH) with the GenoSensor Array 300. Mean number of aberrations detected per tumor was significantly greater for invasive meningiomas-67.4 compared with 40.5 for non-invasive MSR. Additionally, invasive MSR disclosed frequent losses on 1p, 6q, 14q and gains on 15q and 20, which were identified previously as molecular hallmarks of stepwise meningioma progression. Thus, the presence of a complex cytogenetic profile and progression-associated chromosomal aberrations in benign MSR is associated with their increased invasive potential. Inasmuch as no reliable adjuvant therapy for recurrent meningiomas is available thus far, revealed genomic aberrations can provide a potential targets for drug discovery and therapeutic intervention in a future.
Insights
Sphenoid region meningiomas (MSR) can be invasive, with recurrence rates up to 30%. Genomic analysis revealed more chromosomal aberrations in invasive MSR, suggesting these changes drive tumor invasion and offer potential therapeutic targets.
Area of Science:
- Neuro-oncology
- Genomics
- Cancer Biology
Background:
- Sphenoid region meningiomas (MSR) frequently exhibit invasive growth, leading to destruction of adjacent structures and significant recurrence rates (up to 30%).
- Conventional cytogenetic methods have not identified specific aberrations linked to MSR invasiveness.
Purpose of the Study:
- To investigate the genomic differences between invasive and non-invasive MSR using array-based comparative genomic hybridization (array-CGH).
- To identify chromosomal aberrations associated with the invasive potential of MSR.
Main Methods:
- Comparative genomic hybridization using the GenoSensor Array 300 was performed on 10 invasive and 5 non-invasive MSR.
- Analysis focused on identifying differences in the number and location of chromosomal aberrations between the two groups.
Main Results:
- Invasive MSR showed a significantly higher mean number of detected aberrations (67.4) compared to non-invasive MSR (40.5).
- Frequent chromosomal losses on 1p, 6q, 14q and gains on 15q and 20 were observed in invasive MSR, consistent with known progression markers.
- A complex genomic profile and specific progression-associated aberrations correlate with increased invasive potential in MSR.
Conclusions:
- The study identifies a complex genomic profile and specific chromosomal aberrations associated with the invasive behavior of MSR.
- These genomic alterations may serve as potential targets for future drug discovery and therapeutic interventions for recurrent meningiomas.
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