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Updated: Aug 7, 2026
12:22
The Use of Reverse Phase Protein Arrays (RPPA) to Explore Protein Expression Variation within Individual Renal Cell Cancers
Published on: January 22, 2013
Molecular targeting therapy for renal cell carcinoma
1Department of Urology, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan. etom@uro.med.kyushu-u.ac.jp
International Journal of Clinical Oncology
|July 20, 2006
Summary
New targeted therapies show promise for metastatic renal cell carcinoma (RCC), a difficult-to-treat cancer. Vascular Endothelial Growth Factor Receptor (VEGFR) pathway inhibitors are demonstrating significant clinical activity in advanced RCC.
Area of Science:
- Oncology
- Molecular Biology
- Pharmacology
Background:
- Metastatic renal cell carcinoma (RCC) presents significant treatment challenges due to its resistance to conventional therapies.
- Recent advancements in understanding RCC molecular pathways have paved the way for novel therapeutic strategies.
Purpose of the Study:
- To review the development and clinical application of targeted therapies for metastatic RCC.
- To highlight the role of vascular endothelial growth factor receptor (VEGFR) pathway inhibition in treating advanced RCC.
Main Methods:
- Review of recent clinical trials and FDA-approved agents targeting VEGFR and related kinases.
- Analysis of the molecular mechanisms targeted by new RCC therapies.
Main Results:
- Two multi-kinase inhibitors (BAY 43-9006 and SU 11248) targeting VEGFR, PDGFR, FLT3, KIT, and Raf kinase are FDA-approved for advanced RCC.
- Ongoing Phase III trials are evaluating VEGF inhibition combined with interferon alpha (IFN-alpha).
- VEGF inhibition has shown promising clinical responses in historically resistant RCC.
Conclusions:
- VEGF pathway inhibition represents a significant breakthrough in the treatment of advanced metastatic renal cell carcinoma.
- Ongoing research and clinical trials are crucial to further define the role of these novel agents in RCC management.
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