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Preparation of Stable Bicyclic Aziridinium Ions and Their Ring-Opening for the Synthesis of Azaheterocycles
Published on: August 22, 2018
Dynamic kinetic resolution and desymmetrization processes: a straightforward methodology for the enantioselective
Mercedes Amat1, Oriol Bassas, Núria Llor
1Laboratory of Organic Chemistry, Faculty of Pharmacy University of Barcelona, Av. Joan XXIII s/n, 08028 Barcelona, Spain. amat@ub.edu
Abstract:
A straightforward procedure for the synthesis of enantiopure polysubstituted piperidines is reported. It involves the direct generation of chiral non-racemic oxazolo[3,2-a]piperidone lactams that already incorporate carbon substituents on the heterocyclic ring and the subsequent removal of the chiral auxiliary. The key step is a cyclocondensation reaction of (R)-phenylglycinol or other amino alcohols with racemic or prochiral delta-oxo (di)acid derivatives in highly stereoselective processes involving dynamic kinetic resolution and/or desymmetrization of diastereotopic or enantiotopic ester groups.
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