Related Experiment Videos
[Primary non-Hodgkin orbital lymphoma: case report]
Sanda Rozanković1, Renata Iveković, Katia Novak-Laus
1Klinika za ocne bolesti, Klinicka bolnica Sestre Milosrdnice, Zagreb, Hrvatska. sanda.rozankovic@sk.t-com.hr
Summary
This case report details a rare orbital lymphoma in an elderly woman, successfully treated with surgery and chemotherapy. Early diagnosis and interdisciplinary care were crucial for recovery.
Area of Science:
- Ophthalmology
- Oncology
- Hematology
Background:
- Primary malignant non-Hodgkin orbital lymphoma is exceedingly rare.
- Orbital lymphomas can present with rapid compression of ocular structures.
Observation:
- An 80-year-old female presented with rapid orbital structure compression due to a solid neoplastic process.
- Imaging revealed a mass dislocating the eyeball without invasion of surrounding orbital structures.
Findings:
- Histopathology confirmed diffuse large B-cell lymphoma, a type of non-Hodgkin lymphoma, with high mitotic activity.
- Immunohistochemistry showed CD 20 positive B lymphocytes and kappa light chain expression.
- The patient responded well to surgical debulking and three cycles of CHOP chemotherapy.
Implications:
- This case highlights the importance of a multidisciplinary approach for diagnosing and managing rare orbital malignancies.
- Prompt diagnosis and combined modality treatment can lead to favorable outcomes in orbital lymphoma.
- Further research into rare orbital tumors is warranted to improve patient management strategies.