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Related Experiment Videos

Submicrometer cavity surface plasmon sensors.

Dragos Amarie1, Tiberiu-Dan Onuta, Radislav A Potyrailo

  • 1Departments of Chemistry and Physics, Indiana University, Bloomington, Indiana 47405, USA.

The Journal of Physical Chemistry. B
|July 21, 2006
PubMed
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A novel miniaturized spherical surface plasmon sensor offers high sensitivity for detecting unlabeled molecules. This technology is ideal for microfluidic applications, rivaling commercial planar sensors.

Area of Science:

  • Nanotechnology
  • Biophysics
  • Analytical Chemistry

Background:

  • Surface plasmon resonance (SPR) sensors are crucial for label-free molecular detection.
  • Existing SPR sensors often face limitations in miniaturization and integration into microfluidic systems.
  • Developing compact and highly sensitive SPR sensors is essential for advanced biological and chemical analyses.

Purpose of the Study:

  • To introduce a miniaturized spherical surface plasmon sensor for label-free binding kinetics measurement.
  • To demonstrate the sensor's high sensitivity and submicrometer footprint for microfluidic integration.
  • To investigate the sensor's response to molecular adsorption in both vapor and liquid phases.

Main Methods:

  • Fabrication of a submicrometer metal-coated sphere embedded in an opaque metal film.

Related Experiment Videos

  • Utilizing wavelength shifts of cavity resonances for molecular adsorption detection.
  • Testing sensor response to water and ethanol vapor adsorption.
  • Assessing sensor performance in liquid by detecting dodecanethiol adsorption.

    • Main Results:

    • The spherical SPR sensor exhibits a submicrometer footprint.
    • Sensitivity rivals state-of-the-art commercial planar SPR sensors.
    • The sensor is highly responsive to water and ethanol vapor adsorption.
    • Detection of sub-monolayer adsorption (dodecanethiol, ~1.5 nm) in liquid is achieved.

    Conclusions:

    • The miniaturized spherical SPR sensor is a promising platform for label-free molecular detection.
    • Its small size and high sensitivity enable integration into microfluidic devices.
    • The sensor shows significant potential for diverse applications in chemical and biological sensing.