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Related Experiment Videos

Apomorphine--test in dystonia.

M Langkafel1, A Heinz, L Schöls

  • 1Department of Neurology, University of Bochum, St. Josef-Hospital, Federal Republic of Germany.

Journal of Neural Transmission. Parkinson'S Disease and Dementia Section
|January 1, 1991
PubMed
Summary

Apomorphine injections effectively predicted which patients with dystonic movement disorders would respond to dopaminergic therapy. This test helps identify dopamine sensitivity for better treatment selection in dystonia.

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Area of Science:

  • Neurology
  • Pharmacology

Background:

  • Dystonic movement disorders are characterized by involuntary muscle contractions.
  • Assessing dopamine sensitivity is crucial for effective treatment selection.

Purpose of the Study:

  • To evaluate subcutaneous apomorphine as a predictor of dopaminergic therapy response in dystonia patients.
  • To determine the correlation between apomorphine efficacy and subsequent dopaminergic drug dosage.

Main Methods:

  • A double-blind, placebo-controlled study involving 7 patients with dystonic movement disorders.
  • Subcutaneous apomorphine injections were administered to assess symptom response.
  • Patients were subsequently treated with oral or continuous dopaminergic therapy based on apomorphine test results.

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Main Results:

  • Five out of seven patients showed significant clinical improvement with apomorphine and subsequently responded to dopaminergic therapy.
  • Effective apomorphine doses correlated with the required doses of dopaminergic drugs.
  • Two patients who did not respond to apomorphine also did not benefit from dopaminergic therapy.

Conclusions:

  • Subcutaneous apomorphine serves as a valuable predictive test for dopamine sensitivity in dystonia.
  • This predictive capability can guide the selection of appropriate dopaminergic treatments for improved patient outcomes.