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Published on: August 25, 2021
Deregulated NF-kappaB activity in haematological malignancies
Aurore Keutgens1, Isabelle Robert, Patrick Viatour
1Laboratory of Medical Chemistry, Center for Cellular and Molecular Therapy, Center for Biomedical Integrative Genoproteomics, University of Liege, Tour de Pathologie, +3 B23, CHU Sart-Tilman, 4000 Liège, Belgium.
Abstract:
The NF-kappaB family of transcription factors plays key roles in the control of cell proliferation and apoptosis. Constitutive NF-kappaB activation is a common feature for most haematological malignancies and is therefore believed to be a crucial event for enhanced proliferation and survival of these malignant cells. In this review, we will describe the molecular mechanisms underlying NF-kappaB deregulation in haematological malignancies and will highlight what is still unclear in this field, 20 years after the discovery of this transcription factor.
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