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Related Experiment Videos

Bone marrow-derived cells contribute to infarct remodelling.

Helge Möllmann1, Holger M Nef, Sawa Kostin

  • 1Kerckhoff Heart Center, Benekestrasse 2-8, 61231 Bad Nauheim, Germany. h.moellmann@kerckhoff.mpg.de

Cardiovascular Research
|July 21, 2006
PubMed
Summary

Bone marrow cells (BMC) rarely become cardiomyocytes after heart attack. Instead, BMC primarily form scar tissue fibroblasts and myofibroblasts, contributing to cardiac repair and remodeling.

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Area of Science:

  • Cardiovascular Research
  • Stem Cell Biology
  • Regenerative Medicine

Background:

  • Cardiac myocytes were traditionally considered terminally differentiated.
  • Recent studies suggested bone marrow-derived cells (BMC) could transdifferentiate into cardiomyocytes, but findings were controversial.
  • This study investigated BMC contribution to cardiac repair post-myocardial infarction.

Purpose of the Study:

  • To investigate the contribution and potential transdifferentiation of BMC into cardiomyocytes and other cell types.
  • To analyze BMC behavior during the remodeling process in experimental myocardial infarction.
  • To clarify the role of BMC in cardiac repair.

Main Methods:

  • Bone marrow transplantation from eGFP-transgenic mice into irradiated wild-type mice.

Related Experiment Videos

  • Induction of myocardial infarction via coronary artery ligation.
  • Immunohistochemical analysis of heart sections using cell-specific markers and eGFP.
  • Fluorescence and confocal laser microscopy for cell identification and localization.

    • Main Results:

    • Successful bone marrow transplantation confirmed by FACS analysis.
    • Significant infiltration of inflammatory cells (CD45+/eGFP+) post-infarction.
    • Very few eGFP-positive cardiomyocytes observed, indicating negligible transdifferentiation.
    • Abundant BMC-derived fibroblasts and myofibroblasts found in the infarct area.
    • BMC contributed to scar tissue neoangiogenesis but not to angiogenesis in other zones.

    Conclusions:

    • Transdifferentiation of BMC into cardiomyocytes is a negligible event in myocardial repair.
    • BMC-derived fibroblasts and myofibroblasts play a significant role in post-infarction scar formation.
    • BMC-driven neoangiogenesis contributes to scar tissue remodeling.