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Updated: Aug 7, 2026

Use of Pre-Assembled Plastic Microfluidic Chips for Compartmentalizing Primary Murine Neurons
Published on: November 2, 2018
Distinct roles of diverse nuclear factor-kappaB complexes in neuropathological mechanisms
Marina Pizzi1, Pierfranco Spano
1Division of Pharmacology and Experimental Therapeutics, Department of Biomedical Sciences and Biotechnologies, School of Medicine, University of Brescia, I 25123, Italy. pizzi@med.unibs.it
Abstract:
The nuclear transcription factors kappaB (NF-kappaB) function as key regulators of physiological processes in the central nervous system. Aberrant regulation of NF-kappaB can underlie neurological disorders associated with neurodegeneration. A large number of studies have reported a dual role of NF-kappaB in regulating neuron survival in pathological conditions. A recent progress in understanding the mechanisms responsible for opposite effects elicited by NF-kappaB in brain dysfunctions arises from the identification of diverse NF-kappaB complexes specifically involved in the mechanism of neuronal cell death or cell survival. We here discuss the latest findings and consider the therapeutic potential of targeting distinct NF-kappaB complexes for the treatment of neurodegenerative disorders and memory dysfunctions.
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