Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Differential activation of ventrolateral prefrontal cortex during working memory retrieval.

Robert Christian Wolf1, Nenad Vasic, Henrik Walter

  • 1Department of Psychiatry III, University of Ulm, Leimgrubenweg 12-14, 89075 Ulm, Germany. christian.wolf@uni-ulm.de

Neuropsychologia
|July 21, 2006
PubMed
Summary

This study reveals how the brain recruits prefrontal cortex areas for working memory (WM) retrieval. Ventral prefrontal cortex shows distinct activation patterns when distinguishing between targets and non-targets.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

<i>N</i>-Acetylcysteine and a Specialized Preventive Intervention for Individuals at High Risk for Psychosis: A Randomized Double-Blind Multicenter Trial.

Schizophrenia bulletin open·2024
Same author

Influences of heart rate feedback and autistic traits on affective mindreading.

Scientific reports·2024
Same author

Design studies for clinical prediction.

Science (New York, N.Y.)·2024
Same author

The architecture of paranoia in the general population: A self-report and ecological momentary assessment study.

Schizophrenia research·2024
Same author

Investigating grey matter volumetric trajectories through the lifespan at the individual level.

Nature communications·2024
Same author

Coupled changes between ruminating thoughts and resting-state brain networks during the transition into adulthood.

Molecular psychiatry·2024

Area of Science:

  • Neuroscience
  • Cognitive Neuroscience
  • Neuroimaging

Background:

  • Prefrontal cortex involvement in working memory (WM) retrieval is suggested by prior brain imaging studies.
  • Understanding the neural mechanisms of gradual information retrieval in WM is crucial for cognitive science.

Purpose of the Study:

  • To investigate the gradual recruitment of brain areas during verbal WM retrieval using event-related functional magnetic resonance imaging (fMRI).
  • To examine activation differences in prefrontal cortex during the retrieval of negative (non-target) versus positive (target) probes.

Main Methods:

  • Utilized event-related fMRI with a modified Sternberg Item Recognition Paradigm.
  • Fifteen subjects performed a verbal WM task involving retrieval of up to three letters.

Related Experiment Videos

  • Parametrically varied retrieval demand and analyzed activation differences for negative and positive probes.

    • Main Results:

    • Bilateral ventrolateral prefrontal cortex (VLPFC) activation was observed during single-item retrieval.
    • Gradual increases in activation were noted in left VLPFC (BA 47), anterior PFC (BA 10), and bilateral dorsolateral PFC (BA 9) with increasing WM load.
    • VLPFC (BA 47) exhibited greater activation in response to negative probes compared to positive probes.

    Conclusions:

    • The findings demonstrate a gradual recruitment of prefrontal cortex regions with increasing working memory retrieval demand.
    • Ventral prefrontal cortex areas appear differentially involved in discriminating non-targets from targets within a retrieved set.