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Updated: Aug 7, 2026

An Immunohistopathologic Study to Profile the Folate Receptor Beta Macrophage and Vascular Immune Microenvironment in Giant Cell Arteritis
Published on: February 8, 2019
[Ortner's syndrome and giant-cell vasculitis]
1Service de médecine interne, site A.-Boulloche, CHG Belfort-Montbeliard, 4, rue du Docteur-Flamand, 25209 Belfort-Montbéliard, France.
Giant cell arteritis (GCA), also known as Horton's disease, may cause Ortner's syndrome, characterized by hoarseness due to left vocal cord palsy and aortic aneurysm. This case highlights GCA as a potential etiology.
Area of Science:
- Cardiology
- Neurology
- Rheumatology
Context:
- Ortner's syndrome, typically linked to mitral stenosis, involves left laryngeal nerve palsy.
- Aortic aneurysms are a known, though less common, cause of Ortner's syndrome.
- Giant cell arteritis (GCA) is an inflammatory condition affecting large arteries.
Purpose:
- To report a case of Ortner's syndrome associated with GCA and aortic arch aneurysm.
- To explore the potential link between GCA and cardio-vocal syndrome.
Summary:
- A 90-year-old woman with temporal arteritis presented with hoarseness and was diagnosed with an aortic arch aneurysm and left vocal cord palsy.
- This presentation suggests GCA as a possible cause of Ortner's syndrome, expanding its known etiologies.
Impact:
- Broadens the understanding of Ortner's syndrome etiologies.
- Suggests considering GCA in patients with hoarseness and aortic pathology.
- Highlights the importance of a multidisciplinary approach in diagnosing rare conditions.
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