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Are neurologic examination abnormalities heritable? A preliminary study.

R D Sanders1, Y H Joo, L Almasy

  • 1Dayton VA, Dayton, OH, USA.

Schizophrenia Research
|July 21, 2006
PubMed
Summary
This summary is machine-generated.

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Neurologic examination abnormalities (NEA) show significant heritability in families, suggesting they may be schizophrenia endophenotypes. These neurological measures also correlate with neurocognitive functions, supporting their construct validity.

Area of Science:

  • Neuroscience
  • Psychiatry
  • Genetics

Background:

  • Neurologic examination abnormalities (NEA) are more common in schizophrenia patients and their relatives than in controls.
  • NEA may represent endophenotypes for schizophrenia, indicating a genetic link.
  • Previous research suggests a need to estimate the heritability of NEA and its relationship with cognitive function.

Purpose of the Study:

  • To estimate the heritability of specific NEA in extended families.
  • To evaluate the correlations between NEA and cognitive performance to assess construct validity.
  • To investigate familial influences on neurological and neurocognitive measures in schizophrenia.

Main Methods:

  • Studied eight extended families with relatives affected by schizophrenia or schizoaffective disorder (n=96).

Related Experiment Videos

  • Utilized a modified Neurological Evaluation Scale (NES) with untransformed data (e.g., error counts, completion time).
  • Estimated heritability using the variance component method (SOLAR) and performed correlational analyses.

    • Main Results:

    • Significant heritability (h2) estimates were found for several NEA measures, including rapid alternating movements, alternating fist-palm test, fist-ring test, and go-no go task.
    • Heritability analyses were limited by insufficient data variability for some measures.
    • Correlations indicated that repetitive motor tasks relate to cognitive domains (except executive functioning), while cognitive-perceptual tasks relate to memory and executive functioning.

    Conclusions:

    • Detected significant familial influences on specific neurological performance aspects.
    • These heritable neurological measures demonstrate correlations with heritable neurocognitive measures.
    • Findings support the role of NEA as potential endophenotypes for schizophrenia and highlight their connection to cognitive function.