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Updated: Aug 7, 2026

In Vivo and Ex Vivo Approaches to Study Ovarian Cancer Metastatic Colonization of Milky Spot Structures in Peritoneal Adipose
Published on: October 14, 2015
Orbital metastasis from ovarian carcinoma in a patient with BRCA-2 mutation
Rishi P Singh1, Sara Tullis, Mark Hatton
1Eye Plastics, Orbit, and Cosmetic Surgery, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts 02114, USA.
Abstract:
A 45-year-old woman with BRCA-2 mutation-positive ovarian carcinoma had pain, swelling, and proptosis of her left eye. CT demonstrated a mass in the left orbit. Fine-needle aspiration and lateral orbitotomy were used to obtain tissue for diagnosis. Pathology confirmed poorly differentiated tumor cells consistent with ovarian carcinoma. Cytopathologic testing confirmed receptor and hormonal markers within the orbital specimen that were identical to specimens removed 4 years prior.
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