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The prevalence of anaemia depends on the definition: an example from the Aboriginal Birth Cohort Study
1Menzies School of Health Research, Casuarina, Northern Territory, Australia. Dorothy.Mackerras@foodstandards.gov.au
Insights
Different anaemia definitions from WHO and US lead to varied prevalence rates in Aboriginal children. This highlights potential issues in identifying groups for anaemia intervention programs.
Area of Science:
- Paediatric Haematology
- Public Health
- Epidemiology
Background:
- Anaemia diagnosis relies on haemoglobin and haematocrit cutoffs, with differing recommendations from the World Health Organization (WHO) and the United States (US).
- Variations in these diagnostic criteria can impact the estimated prevalence of anaemia and the identification of at-risk populations.
Purpose of the Study:
- To compare anaemia prevalence estimates using WHO and US criteria in Australian Aboriginal children.
- To investigate the underlying reasons for discrepancies in prevalence rates between the two sets of criteria.
Main Methods:
- A cross-sectional survey was conducted on 517 Australian Aboriginal children aged 9-13 years.
- Data collection involved home interviews and blood sample analysis.
Main Results:
- Anaemia prevalence varied significantly, ranging from 6% to 24.4% depending on the criteria used.
- The WHO criteria identified 12-13-year-old girls as a high-prevalence group, while US criteria indicated 12-13-year-old boys as having the highest, though not statistically significant, prevalence.
- Simulations revealed that inconsistent centiles in age-sex specific haemoglobin and haematocrit distributions underlie the WHO cutoffs, explaining the divergent results.
Conclusions:
- The variability in anaemia diagnostic criteria can lead to misidentification of target groups for intervention programs.
- Standardizing or carefully considering diagnostic criteria is crucial for effective public health strategies in paediatric anaemia.
Objective:
The cutoffs defining anaemia based on haemoglobin and haematocrit recommended by the World Health Organization (WHO) and the United States (US) are different. We compared the prevalences resulting from these definitions and explored the reasons for the variation observed.
Design:
A cross-sectional survey within a cohort study of children recruited at birth at Royal Darwin Hospital.
Setting:
Subjects were interviewed in their homes or other convenient location and had a blood sample drawn.
Subjects:
Five hundred and seventeen Australian Aboriginal children aged 9-13 years inclusive.
Results:
Depending on the criterion used, the prevalence of anaemia in the total group ranged between 6% (95% confidence interval: 4.1-8.4%) and 24.4% (20.7-28.3). Using the WHO criteria, girls aged 12-13 years were identified as a target group, having a two- to-six fold higher prevalence than the other groups. When compared to the US criteria, boys aged 12-13 years had the highest prevalence of anaemia, although this was not significant. Simulations show that the WHO cutoffs are based on inconsistent centiles of the age-sex haemoglobin and haematocrit distributions, and that this largely explains the discrepant results.
Conclusions:
This variability in definition could lead to inappropriate identification of target groups for intervention programmes.
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