Related Experiment Video
Updated: Aug 7, 2026
Establishment of Rat Models Mimicking Gender-affirming Hormone Therapies
Published on: January 10, 2025
Testosterone decreases adiponectin levels in female to male transsexuals
Marta Berra1, Francesca Armillotta, Laura D'Emidio
1Department of Obstetrics and Gynecology, S. Orsola Hospital, Via Massarenti 13, Bologna 40138, Italy.
Aim:
To evaluate the effect of testosterone (T) on adiponectin serum levels in transsexual female patients.
Methods:
We measured adiponectin, leptin, luteinizing hormone and follicle stimulating hormone, T, estradiol, lipid profile, biochemical parameters and body composition in 16 transsexual female patients at baseline and after 6 months of T treatment (100 mg Testoviron Depot /10 days, i.m.).
Results:
Adiponectin levels were 16.9 +/- 7.3 mg/mL at baseline and 13.5 +/- 7.4 mg/mL at month 6 of T treatment (P < 0.05). Leptin and high-density lipoprotein cholesterol decreased significantly, whereas body mass index, waist circumference and lean body mass increased significantly after 6 months of T treatment. No changes in insulin or Homeostasis Model Assessment were detected.
Conclusion:
T can significantly reduce adiponectin serum levels in transsexual female patients.
