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Related Experiment Videos

Tramadol for neuropathic pain.

J Hollingshead1, R M Dühmke, D R Cornblath

  • 1Royal Sussex County Hospital, Eastern Road, Brighton, UK BN2 5BE. james@hollo.org

The Cochrane Database of Systematic Reviews
|July 21, 2006
PubMed
Summary

Tramadol effectively reduces neuropathic pain, with a number needed to treat of 3.8 for significant pain relief compared to placebo. This systematic review confirms tramadol

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Area of Science:

  • Neurology
  • Pharmacology
  • Pain Management

Background:

  • Peripheral neuropathic pain presents with diverse symptoms like burning sensations and heightened sensitivity to stimuli.
  • It is a prevalent symptom across various peripheral nervous system disorders.

Purpose of the Study:

  • To systematically review randomized controlled trials (RCTs) evaluating the efficacy of tramadol for neuropathic pain.
  • To assess tramadol's effectiveness against placebo and other analgesics.

Main Methods:

  • Searched multiple databases (Cochrane, MEDLINE, EMBASE, LILACS) up to June 2005 for RCTs and quasi-RCTs.
  • Included trials comparing tramadol with placebo, other treatments, or no treatment for neuropathic pain.
  • Extracted data, scored quality, and performed meta-analysis for effectiveness and adverse effects.

Main Results:

  • Four placebo-controlled trials indicated tramadol significantly reduced neuropathic pain.
  • Meta-analysis of three trials (269 participants) showed a number needed to treat (NNT) of 3.8 for at least 50% pain relief.
  • Tramadol demonstrated efficacy in reducing paresthesia, allodynia, and touch-evoked pain.
  • Number needed to harm (NNH) for treatment withdrawal due to side effects was 8.3.

Conclusions:

  • Tramadol is established as an effective pharmacological intervention for neuropathic pain.
  • Evidence supports tramadol's use for specific neuropathic pain symptoms.
  • Further research is needed to compare tramadol with other analgesics like clomipramine and morphine.

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