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Nedocromil sodium for chronic asthma in children
1Leicester Royal Infirmary, Department of Child Health, Clinical Sciences Building, Leicester, Leicestershire, UK LE1 5WW. sa135@le.ac.uk
The Cochrane Database of Systematic Reviews
|July 21, 2006
Summary
Nedocromil sodium shows some short-term benefits for childhood asthma, but long-term efficacy is conflicting. It has a good safety profile, though more head-to-head trials are needed against inhaled corticosteroids.
Area of Science:
- Pediatric Pulmonology
- Pharmacology
- Clinical Trials
Background:
- Inhaled corticosteroids (ICS) are standard for childhood asthma maintenance.
- Long-term side effects of ICS in children remain unclear.
Purpose of the Study:
- To compare the safety and efficacy of inhaled nedocromil sodium versus placebo in treating chronic asthma in children.
- To evaluate nedocromil sodium's role in pediatric asthma management.
Main Methods:
- Systematic review of randomized placebo-controlled trials.
- Searched multiple databases and contacted drug manufacturers and authors.
- Included 15 trials with 1422 children (0-18 years).
Main Results:
- Short-term studies showed nedocromil improved lung function (FEV1, FVC) and symptom scores.
- Parental assessment favored nedocromil (OR 0.5).
- Nedocromil has a good safety profile; unpleasant taste was the main side effect.
Conclusions:
- Conflicting evidence exists on nedocromil's long-term efficacy for asthma control.
- Short-term benefits observed, but long-term effects are inconsistent.
- Further head-to-head trials with ICS are needed to clarify nedocromil's place in therapy.
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