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Copper containing, framed intra-uterine devices for contraception
R Kulier1, F M Helmerhorst, P O'Brien
1Geneva Foundation for Medical Education and Research, Route de Florissant 3, Geneva, Switzerland CH-1208. regina.kulier@bluewin.ch
The Cochrane Database of Systematic Reviews
|July 21, 2006
Summary
The TCu380A intrauterine device (IUD) is more effective than other copper IUDs. No significant differences in side effects were observed between TCu380A and other IUDs, but more research is needed for specific populations.
Area of Science:
- Reproductive Health
- Contraception Technology
- Medical Device Efficacy
Background:
- Intrauterine devices (IUDs) are safe and effective long-term reversible contraceptives.
- Variations in IUD design and copper content may influence effectiveness and side effect profiles.
Purpose of the Study:
- To compare the effectiveness and side effects of different copper intrauterine devices (IUDs).
Main Methods:
- Systematic review and meta-analysis of 34 randomized controlled trials.
- Data extraction and analysis performed by two independent reviewers.
- Outcomes compared using rate difference with 95% confidence intervals.
Main Results:
- TCu380A demonstrated higher effectiveness compared to MLCu375, MLCu250, TCu220, and TCu200.
- Modifications to TCu380A (TCu380S) did not enhance efficacy.
- No significant differences in bleeding, pain, or discontinuation rates were found between TCu380A and other IUDs.
Conclusions:
- TCu380A is the most effective copper IUD based on current evidence.
- Further research is needed to compare IUDs in specific subgroups, such as nulliparous women.