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Related Experiment Videos

Garlic for preventing pre-eclampsia and its complications.

S Meher1, L Duley

  • 1University of Liverpool, Division of Perinatal and Reproductive Medicine, First Floor, Liverpool Women's NHS Foundation Trust, Crown Street, Liverpool, UK L8 7SS. s.meher@liv.ac.uk

The Cochrane Database of Systematic Reviews
|July 21, 2006
PubMed
Summary

Current evidence is insufficient to recommend garlic for preventing pre-eclampsia. While garlic intake may cause odor, further large randomized trials are needed to guide clinical practice for pre-eclampsia prevention.

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Area of Science:

  • Obstetrics and Gynecology
  • Integrative Medicine
  • Nutritional Science

Background:

  • Garlic's potential blood pressure-lowering, anti-platelet, and antioxidant properties suggest a role in pre-eclampsia prevention.
  • Pre-eclampsia is a serious pregnancy complication with significant maternal and fetal risks.

Purpose of the Study:

  • To evaluate the efficacy of garlic in preventing pre-eclampsia and its associated complications through a systematic review of randomized trials.

Main Methods:

  • Searched major databases including Cochrane Pregnancy and Childbirth Group Trials Register, Cochrane Central Register of Controlled Trials, and EMBASE.
  • Included randomized controlled trials comparing garlic with placebo for pre-eclampsia prevention.
  • Independently selected trials, extracted data, and analyzed results using Review Manager software.

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Main Results:

  • One low-quality trial with 100 women compared garlic to placebo; another study was excluded due to high loss to follow-up.
  • No significant differences were observed between garlic and placebo groups for developing gestational hypertension or pre-eclampsia.
  • Garlic use was associated with a higher likelihood of reporting odor, but not other significant adverse effects.

Conclusions:

  • Insufficient evidence exists to support increased garlic consumption for pre-eclampsia prevention.
  • While generally safe regarding serious side-effects, garlic is associated with odor.
  • Large-scale, high-quality randomized trials are necessary to establish clinical recommendations for garlic in pre-eclampsia management.