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Related Experiment Videos

Plasma protein synthesis after spaceflight.

T Peter Stein1, Margaret D Schluter

  • 1Department of Surgery, University of Medicine and Dentistry of New Jersey - SOM, Stratford, NJ 08084, USA. tpstein@umdnj.edu

Aviation, Space, and Environmental Medicine
|July 22, 2006
PubMed
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Spaceflight causes astronauts to enter a protein-depleted state. Postflight, plasma protein synthesis rates decrease, suggesting amino acid competition limits muscle recovery.

Area of Science:

  • Space physiology
  • Biochemistry
  • Nutrition science

Background:

  • Astronauts experience protein depletion during spaceflight.
  • Postflight, muscle protein anabolism occurs, but dietary protein intake does not significantly increase.
  • Competition for amino acids between muscle and other tissues may impair protein synthesis.

Purpose of the Study:

  • To investigate plasma protein synthesis rates after spaceflight.
  • To test the hypothesis that substrate competition for amino acids limits protein synthesis in other tissues postflight.

Main Methods:

  • Measured fractional protein synthesis rates (FSR) of four plasma proteins (fibrinogen, C-3, ceruloplasmin, haptoglobin).
  • Utilized the 15N glycine-hippuric acid method before and after a 16-day Space Shuttle flight.

Related Experiment Videos

  • Collected data from four astronauts, with measurements taken preflight and at 0, 6, and 14 days postflight.

    • Main Results:

    • Plasma protein synthesis rates were significantly reduced 6 days after landing compared to preflight levels.
    • This reduction indicates a potential impairment in the body's ability to synthesize essential proteins post-mission.

    Conclusions:

    • Plasma protein synthesis is depressed following spaceflight.
    • These findings support the hypothesis that amino acids become a limiting factor due to substrate competition between muscle and other tissues for recovery.