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Neonatal cholestasis in Thai infants.

Prapun Aanpreung1, Mongkol Laohapansang, Ravit Ruangtrakool

  • 1Department of Pediatrics, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand. sipap@mahidol.ac.th

Journal of the Medical Association of Thailand = Chotmaihet Thangphaet
|July 22, 2006
PubMed
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Idiopathic neonatal hepatitis and extrahepatic biliary atresia are common causes of neonatal cholestasis in Thai infants. Total parenteral nutrition-related cholestasis is increasing, but overall prognosis is good.

Area of Science:

  • Pediatrics
  • Neonatology
  • Gastroenterology

Background:

  • Neonatal cholestasis is a critical condition in infants.
  • Understanding its causes and outcomes is vital for effective management.

Purpose of the Study:

  • To investigate the etiologies and outcomes of neonatal cholestasis in Thai infants.
  • To identify trends in causes, including the impact of advanced medical care.

Main Methods:

  • Retrospective review of medical records for infants under 3 months diagnosed with neonatal cholestasis.
  • Data collected from 1993 to 2004 at Siriraj Hospital.
  • Etiologies determined through history, physical examination, and investigations.

Main Results:

Related Experiment Videos

  • 252 infants were included: 135 males (53.6%) and 117 females (46.4%).
  • Most common etiologies: Idiopathic Neonatal Hepatitis (23%), Extrahepatic Biliary Atresia (22.2%), Total Parenteral Nutrition-related cholestasis (18.3%).
  • TPN-related cholestasis increased due to care for premature infants; Inborn errors of metabolism were rare (3.21%).

    • Conclusions:

    • Idiopathic neonatal hepatitis and EHBA remain leading causes of neonatal cholestasis.
    • TPN-related cholestasis is rising, reflecting advancements in critical care for premature infants.
    • Neonatal cholestasis in Thai infants has a good short-term prognosis.