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Related Experiment Videos

Fetal warfarin syndrome.

Achara Sathienkijkanchai1, Pornswan Wasant

  • 1Division of Medical Genetics, Department of Pediatrics, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand.

Journal of the Medical Association of Thailand = Chotmaihet Thangphaet
|July 22, 2006
PubMed
Summary

Fetal warfarin syndrome, a condition caused by prenatal warfarin exposure, can lead to severe birth defects like nasal hypoplasia. This report details the first documented case in Thailand, highlighting the risks of warfarin during pregnancy.

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Area of Science:

  • Teratology
  • Developmental Biology
  • Pharmacology

Background:

  • Warfarin use during pregnancy poses risks for fetal development.
  • Fetal Warfarin Syndrome (FWS) is characterized by specific embryopathic features.
  • Identifying and managing FWS is crucial for prenatal care.

Observation:

  • A case of FWS is reported in Thailand, a first for the region.
  • The infant presented with severe nasal hypoplasia, respiratory distress, and limb abnormalities.
  • Maternal history included SLE and arterial embolism, with warfarin use during an unplanned pregnancy.

Findings:

  • The infant exhibited classic FWS features: nasal hypoplasia and stippled epiphyses.
  • Radiographic evidence confirmed epiphyseal calcifications in long bones and vertebrae.

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  • The infant succumbed to respiratory failure at six months of age.

    • Implications:

    • This case underscores the teratogenic potential of warfarin, even in unplanned pregnancies.
    • Increased awareness and surveillance for FWS in Thailand are warranted.
    • Alternative anticoagulation strategies should be considered for women of childbearing potential.