[Histomorphological tubulointerstitial changes in progression of chronic glomerulonephritis]

The role of histological changes associated with primary types of glomerulonephritides in progression of chronic glomerulonephritis (CGN) is analysed. It is shown that CGN progression acceleration occurs much more frequently if chronic renal failure arises within 7 years since the disease onset, in the presence of concomitant tubulointerstitial changes (TIC)in unfavorable morphological types--mesangiocapillary glomerulonephritis and focal-segmental hyalinosis/ sclerosis. It was found that more frequent occurrence of CGN accelerated progression in unfavorable morphological types and TIC depends on the presence of unfavorable clinical types--active nephritic and nephrotic-hypertensive types (classification of M. Ya. Ratner et al.). In TIC there were primarily unfavorable clinical types which contribute to accelerated progression of CGN. This relationship is explained by involvement of factors belonging to the above clinical types in the mechanism of the morphological changes. In these clinical types CGN accelerated progression takes place irrespectively of the presence of TIC and unfavorable morphological types.