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Updated: Aug 7, 2026
Synthesis of Stimuli-responsive Nanogels using Aqueous One-step Crosslinking and Co-nanopolymerization
Published on: January 24, 2025
[Preparation of gelatin nanogel modified with fluoride anion and its ultrasonic triggered release characteristics]
Dao-cheng Wu1, Ming-xi Wan, Hong Wu
1The Key Laboratory of Biomedical Information Engineering of Ministry of Education, Xi'an Jiaotong University, China. wudaocheng@mail.xjtu.edu.cn
Aim:
To investigate the preparation, shape and ultrasound triggered release characteristics of gelatin nanogel modified with fluoride anion.
Methods:
Adriamycin gelatin nanogel modified with fluoride anion (ADM-FMNG) was prepared by co-precipitation with fluoride anion. The content and encapsulation rate of adriamycin were measured by HPLC method. The size and shape of ADM-FMNG were determined by electron microscope. The size and distribution of ADM-FDNG before and after sonication were measured by laser size analysis device.
Results:
The average diameter of ADM-FMNG was (46 +/- 12) nm. Adriamycin encapsulated rate and loading were 87.2% and 0.091 g x L(-1), respectively. 48.5% of adriamycin was released within 50 h while in vitro at 37 degrees C. Under the action of ultrasound that has the frequency of 20 kHz, 0.4 W x cm(-2) of power density and 7-8 min duration, 51. 5% of adriamycin in ADM-FMNG was released that was significantly higher than control group, the size of ADM-FMNG was changed from (46 +/- 12) nm to (1,212 +/- 35) nm and restored after ultrasound stopped for 3-4 min.
Conclusion:
ADM-FDNG system has the sensitive ultrasound triggered release characteristics.
