[Synthesis and anti-inflammatory activity of hydroxylated E,E-1-(3'-indolyl)-5-(substituted
Xiao-he Guo1, Sen-xiang Cheng, Gui-fang Cheng
1Department of Chemistry , University of Science and Technology of China, Hefei.
Aim:
A series of new 1,4-pentadien-3-one derivatives were synthesized to search for new Eight novel hydroxylated non-steroidal anti-inflammatory drugs (NSAIDs) with potent activity.
Methods:
E,E-1-(3'-indolyl)-5-( substituted phenyl)-1,4-pentadien-3-one derivatives were synthesized by means of aldol condensation and characterized by 1H NMR, ESI-MS and element analysis. Their anti-inflammatory activity in vitro were evaluated.
Results:
Preliminary in vitro pharmacological tests showed that all compounds exhibited anti-inflammatory activity.
Conclusion:
Compounds 4d and 4e exhibited potent anti-inflammatory activity and their anti-inflammatory activity was comparable to resveratrol, and were worthy of further study.
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