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Updated: Aug 7, 2026

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Transplantation of a 3D Bioprinted Patch in a Murine Model of Myocardial Infarction
Published on: September 26, 2020
[Postinfarction ventricular septal perforation; tips of patch closure]
N Sakagoshi1, T Yamaguchi, Y Kobayashi
1Department of Cardiac Surgery, Kawachi General Hospital, Higashi-Osaka, Japan.
Kyobu Geka. the Japanese Journal of Thoracic Surgery
|July 22, 2006
Summary
This study presents a modified patch closure technique for postinfarction ventricular septal perforation (VSP) repair. The method aims to prevent low output syndrome (LOS) and residual shunts, showing good results in six patients.
Area of Science:
- Cardiovascular Surgery
- Cardiac Repair Techniques
- Myocardial Infarction Complications
Background:
- Surgical repair of postinfarction ventricular septal perforation (VSP) is complex.
- Low output syndrome (LOS) and residual shunts are significant postoperative complications.
- Existing methods include patch closure and David procedures.
Observation:
- A modified patch closure technique is detailed.
- Key modifications include minimal septal resection and specific suture placement.
- A large xeno-pericardial patch with an extended skirt is utilized to manage potential myocardial cutting and shunt flow.
Findings:
- The technique was applied to six patients with postinfarction VSP.
- The modified approach aims to prevent residual shunts by leveraging left ventricular pressure.
- Postoperative outcomes were reported as good, suggesting efficacy in preventing complications.
Implications:
- This technique offers a potential strategy to reduce LOS and residual shunts after VSP repair.
- The use of a xeno-pericardial patch skirt may provide a novel method for managing intraoperative challenges.
- Further studies could validate this approach in a larger patient cohort.
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