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Plasma tocopherol levels: a preliminary reference range.

Simmi Kharb1, G P Singh, Veena Singh Ghalaut

  • 1Department of Biochemistry, Pt BD Sharma PGIMS, Rohtak.

Journal of the Indian Medical Association
|July 22, 2006
PubMed
Summary
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This study established reference values for alpha-tocopherol (vitamin E) in healthy adults. Men showed higher levels than women, and older individuals had lower vitamin E levels, impacting antioxidant defense evaluation.

Area of Science:

  • Biochemistry
  • Human Physiology
  • Nutritional Science

Background:

  • Alpha-tocopherol, a key antioxidant, plays a crucial role in protecting cells from oxidative stress.
  • Establishing accurate reference ranges for alpha-tocopherol is essential for clinical assessment of antioxidant status.
  • Previous studies have suggested potential variations in alpha-tocopherol levels based on demographic factors.

Purpose of the Study:

  • To determine reliable reference values for serum alpha-tocopherol levels in a healthy adult population.
  • To investigate potential differences in alpha-tocopherol concentrations related to sex and age.
  • To provide data that can aid in the evaluation of antioxidant defense mechanisms.

Main Methods:

  • Spectrofluorometric analysis was employed to quantify alpha-tocopherol levels.

Related Experiment Videos

  • A cohort of 279 healthy volunteers participated in the study.
  • Statistical analyses were performed to compare levels across different sex and age groups.

    • Main Results:

    • The study identified specific reference values for alpha-tocopherol in healthy individuals.
    • Men exhibited significantly higher alpha-tocopherol levels compared to women (p<0.05).
    • A negative correlation was observed between age and alpha-tocopherol levels, with older subjects showing lower concentrations.

    Conclusions:

    • The established reference values for alpha-tocopherol can serve as a benchmark for assessing antioxidant status.
    • Sex and age are significant demographic factors influencing alpha-tocopherol levels in healthy adults.
    • These findings contribute to a better understanding of vitamin E