Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Intra-allelic mutation at human telomeres.

B Britt-Compton1, D M Baird

  • 1Department of Pathology, Cardiff University, Heath Park, Cardiff CF14 4XN, U.K.

Biochemical Society Transactions
|July 22, 2006
PubMed
Summary

Human telomeres are dynamic and heterogeneous, with intra-allelic processes potentially driving telomeric mutations. This review explores evidence and mechanisms behind these telomere dynamics.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

High-risk molecular features may eclipse genomic complexity in predicting chronic lymphocytic leukemia outcomes; UK clinical trial insights.

Leukemia·2026
Same author

Telomere length heterogeneity in placenta revealed with high-resolution telomere length analysis.

Placenta·2017
Same author

Telomere fusion threshold identifies a poor prognostic subset of breast cancer patients.

Molecular oncology·2015
Same author

Signalling of DNA damage and cytokines across cell barriers exposed to nanoparticles depends on barrier thickness.

Nature nanotechnology·2011
Same author

Extreme telomere erosion in ATM-mutated and 11q-deleted CLL patients is independent of disease stage.

Leukemia·2011
Same author

Mechanisms of telomeric instability.

Cytogenetic and genome research·2009

Area of Science:

  • Genetics
  • Molecular Biology
  • Genomics

Background:

  • Telomere length maintenance is crucial for genome integrity.
  • Human telomeres exhibit significant dynamism and heterogeneity in length and structure.

Purpose of the Study:

  • To review evidence implicating intra-allelic processes in human telomere dynamics.
  • To discuss putative mechanisms of intra-allelic telomeric mutation.

Main Methods:

  • Review of genetic evidence.
  • Analysis of observations on telomere length and internal repeat structure.
  • Exploration of various lines of evidence for intra-allelic involvement.

Main Results:

  • Human telomeres are highly dynamic and heterogeneous.
  • Meiotic recombination within telomeres appears rare.
  • Intra-allelic processes are implicated in telomere dynamics.

Conclusions:

  • Intra-allelic mechanisms play a significant role in human telomere mutation.
  • Further research into these mechanisms is warranted for understanding genome stability.

Related Experiment Videos