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Genetic mapping of loci for X-linked retinitis pigmentosa
N Dahl1, M Sundvall, U Pettersson
1Department of Medical Genetics, University of Uppsala, Sweden.
Clinical Genetics
|December 1, 1991
Abstract:
Linkage analysis was performed in three Swedish families segregating for X-linked retinitis pigmentosa (XLRP), using five polymorphic DNA markers assigned to Xp. Individual recombination events were analyzed and two- and five-point linkage analysis was undertaken. In one family, a XLRP locus was mapped to the same position as OTC corresponding to RP3. In two families, a disease locus linked to OTC was excluded. In one family, recombination events indicate a locus for XLRP outside the interval (DXS84-OTC-DXS255-DXS14), most likely on the centromeric side of DXS14.