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Updated: Aug 7, 2026
08:01
Synthesis of Monocyte-targeting Peptide Amphiphile Micelles for Imaging of Atherosclerosis
Published on: November 17, 2017
Purine bases and atheromatous plaque
L Terzuoli1, E Marinello, C Felici
1Department of Internal Medicine, Endocrine-Metabolic Sciences and Biochemistry, Siena University, Italy.
Summary
Oxidative stress markers, including uric acid and free radicals, are elevated in carotid artery plaques. This suggests that oxidative degradation of nucleotides contributes to atherosclerosis progression and advanced plaque development.
Area of Science:
- Biochemistry
- Cardiovascular Research
- Oxidative Stress
Background:
- Atherosclerosis is characterized by oxidative stress.
- Understanding the role of oxidative stress in plaque evolution is crucial.
Purpose of the Study:
- To quantify oxidative stress markers in atheromatous plaques.
- To elucidate the role of nucleotide degradation in atherosclerosis.
Main Methods:
- Analysis of hypoxanthine, xanthine, uric acid, allantoin, and free radicals in carotid artery plaques.
- Water extraction of pulverized plaque for oxidative stress factor analysis.
Main Results:
- High levels of uric acid to allantoin peroxidation were observed in plaques.
- Elevated free radical levels were detected in atheromatous plaques.
- Oxidative degradation of nucleotides, including LDL oxidation, was identified.
Conclusions:
- Oxidative stress plays a significant role in the progression of atherosclerotic lesions.
- Nucleotide oxidative degradation contributes to advanced plaque formation.
- Findings enhance comprehension of oxidative stress in atherosclerosis.
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