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Updated: Aug 7, 2026

Optimization of the Retinal Vein Occlusion Mouse Model to Limit Variability
Published on: August 6, 2021
[Clinical features of central retinal vein occlusion complicating exudative retinal detachment]
Xiao-yan Peng1, Jing-zhao Wang, Zhi-hua Li
1Beijing Tongren Ophthalmic Center, Capital University of Medical Sciences, Beijing 100730, China. drpengxy@sohu.com
Objective:
To investigate the clinical features of central retinal vein occlusion (CRVO) complicating exudative retinal detachment (ERD).
Methods:
General health, vision, intraocular pressure, appearance of the fundus and fundus fluorescein angiography (FFA) and the results of ultrasound examination in cases with CRVO complicating ERD were analyzed.
Results:
Eight patients were male and 7 patients were female. Age of those patients ranged from 18 to 42 years, averaged 25 years. Five cases combined with neovascular glaucoma. Initial vision ranged from 0.05 to light perception. There were notably edema and hemorrhage in the macular region. Extensive exudative appeared at the edge of edema and detachment region. The extent of retinal detachment was 2/12 - 5/12 quadrant at sitting position. No collateral vessels were found on the optic disk. FFA showed extensive blockage by the hemorrhages or capillary nonperfusion.
Conclusions:
ERD is a rare and severe complication of CRVO, which usually develops in young patients and combines with neovascular glaucoma. The appearance in fundus and FFA shows a characteristic features.
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