Related Experiment Videos
T cell responses to herpes simplex viruses in humans
1Division of Viral and Rickettsial Diseases, Centers for Disease Control, Atlanta, Georgia 30333.
Reviews of Infectious Diseases
|November 1, 1991
Summary
Cytotoxic T lymphocytes (CTLs) are crucial for controlling herpes simplex virus (HSV) infections. CD4+ T cells are identified as key players in resolving HSV disease, particularly in recurrent infections.
Area of Science:
- Immunology
- Virology
Background:
- Herpes simplex virus (HSV) infections are common, and the immune response plays a critical role in their control.
- Cytotoxic T lymphocytes (CTLs) are implicated in controlling HSV, but direct evidence has been limited.
Purpose of the Study:
- To investigate the role of CTLs, particularly CD4+ T cells, in the resolution of HSV infections.
- To explore the implications of impaired CD4+ T cell function in severe HSV disease.
Main Methods:
- Review of existing evidence including in vitro studies, clinical observations, and adoptive transfer experiments.
- Analysis of human CTL responses to HSV, focusing on T cell phenotypes.
Main Results:
- Evidence suggests CTLs play a significant role in resolving HSV disease.
- CD4+ T cells were identified as a predominant killer cell phenotype in human CTL responses to HSV.
- CD4+ T cells are important for delayed type hypersensitivity and clearing local infections.
Conclusions:
- CD4+ T cells are likely critical for resolving recurrent HSV disease.
- Viral agents that impair CD4+ T cell function, like HIV-1, may increase susceptibility to severe HSV infections.