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Porcine Liver Transplantation Without Veno-Venous Bypass As an Extended Criteria Donor Model
Published on: August 17, 2022
Liver transplantation using donors with Gilbert syndrome
Junichi Kaneko1, Yasuhiko Sugawara, Yoshihiro Maruo
1Artificial Organ and Transplantation Division, Department of Surgery, Graduate School of Medicine, University of Tokyo, Japan.
Transplantation
|July 22, 2006
Summary
Living liver donors with Gilbert's syndrome (GS) are safe for transplantation. Recipients of GS donors experienced higher bilirubin levels post-surgery but had unremarkable recovery, confirming safety.
Area of Science:
- Hepatology
- Genetics
- Transplantation Surgery
Background:
- Serum bilirubin levels are crucial in evaluating living liver donor candidates.
- Gilbert's syndrome (GS) is a common genetic condition causing mild hyperbilirubinemia.
- The safety of living liver donation in candidates with potential GS requires specific evaluation.
Purpose of the Study:
- To assess the safety and outcomes of living liver donation in candidates with suspected Gilbert's syndrome.
- To compare postoperative outcomes between living liver donors with GS and non-GS donors.
- To evaluate the impact of GS in donors on recipient outcomes.
Main Methods:
- Donors with hyperbilirubinemia (>1.5 mg/dl) and normal liver function tests underwent genetic testing.
- Diagnosis of GS was confirmed by identifying mutations in the uridine diphosphate glucuronosyltransferase 1 gene.
- Donors and recipients were categorized into GS (n=6) and non-GS (n=65) groups for comparative analysis.
Main Results:
- All living donors with GS and their recipients experienced an unremarkable postoperative course.
- Recipients of GS donors exhibited higher postoperative serum bilirubin levels compared to recipients of non-GS donors.
- No significant adverse events were reported in either the GS donor or recipient groups.
Conclusions:
- Living donor liver transplantation is a safe procedure for donors with Gilbert's syndrome.
- Recipients of living donors with GS experience transiently elevated bilirubin levels but have safe outcomes.
- Genetic evaluation for GS is a valuable component in the living liver donor selection process.
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