Related Experiment Video
Updated: Aug 7, 2026

A Hyperandrogenic Mouse Model to Study Polycystic Ovary Syndrome
Published on: October 2, 2018
[LOH (late-onset hypogonadism) or the "aging male"]
H Sperling1, F Jockenhövel, W Stackl
1Klinik für Urologie, Kliniken Maria Hilf GmbH, Viersener Strasse 450, 41063 Mönchengladbach. herbert.sperling@mariahilf.de.
Insights
Testosterone deficiency in aging men, or late-onset hypogonadism (LOH), lacks sufficient evidence, posing challenges for specialists. Addressing this gap is crucial for improved patient understanding and treatment beyond current guidelines.
Area of Science:
- Andrology
- Endocrinology
- Urology
Context:
- Late-onset hypogonadism (LOH) in aging males presents diagnostic and therapeutic challenges.
- Current evidence regarding testosterone deficiency in aging men is insufficient.
- This knowledge gap impacts urologists, endocrinologists, and andrologists.
Purpose:
- To highlight the challenges posed by late-onset hypogonadism (LOH).
- To emphasize the need for further research into testosterone deficiency in aging males.
- To advocate for improved patient care beyond existing clinical guidelines.
Summary:
- The study addresses the limited data on testosterone deficiency in aging men, known as late-onset hypogonadism (LOH).
- This deficiency remains a significant challenge for multiple medical specialties.
- There is a call for greater responsibility in advancing research and clinical practice.
Impact:
- Improved understanding of LOH and testosterone deficiency in aging men.
- Development of enhanced diagnostic and treatment strategies.
- Better patient outcomes and care that extends beyond current medical guidelines.
Abstract:
Due to lacking evidence of the data about testosterone deficiency of the aging male or LOH (late-onset hypogonadism), this subject is still a challenge for urologists, endocrinologists, and dermatologists or andrologists. This challenge faces basic research as well as clinical investigations. We have to accept responsibility for solving this challenge to better understand and better treat our patients beyond the scope of current guidelines.
Related Concept Videos
Menopause
Disorders of the Male Reproductive System
Prostate disorders are another major concern. These conditions can impair urinary flow due to the prostate's location around the urethra. Symptoms...
Infertility in Males
Gonadal and Placental Hormones
In males, testosterone is the primary gonadal androgen. It plays a central role in the maturation of male reproductive organs — the penis and testes. Additionally, testosterone is instrumental in the development of secondary sexual characteristics — a deep voice as well as facial and pubic hair growth — and...
The Effect of Aging on Tissues
Hypothalamic-Pituitary Axis