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The bm12 Inducible Model of Systemic Lupus Erythematosus (SLE) in C57BL/6 Mice
Published on: November 1, 2015
Pediatric systemic lupus erythematosus in Siriraj Hospital
Suroj Supavekin1, Wanida Chatchomchuan, Anirut Pattaragarn
1Department of Pediatrics, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand 10700. ssupavekin@hotmail.com
Insights
This study describes pediatric systemic lupus erythematosus (SLE) in 101 patients, noting common symptoms like kidney and skin issues. Findings align with other national and international pediatric SLE research.
Area of Science:
- Pediatric Rheumatology
- Immunology
- Systemic Lupus Erythematosus (SLE)
Background:
- Systemic Lupus Erythematosus (SLE) is a chronic autoimmune disease affecting multiple organ systems.
- Pediatric SLE presents unique challenges in diagnosis and management.
- Understanding the epidemiological and clinical characteristics of pediatric SLE is crucial for improving patient outcomes.
Purpose of the Study:
- To describe the clinical characteristics, manifestations, and laboratory findings of pediatric SLE patients.
- To compare these findings with existing data from national and international studies.
- To provide insights into the disease spectrum in a Thai pediatric population.
Main Methods:
- A descriptive study analyzing data from 101 pediatric patients with SLE treated between 1985 and 2003.
- Review of existing patient database to identify eligible cases with available data.
- Collection and analysis of demographic, clinical, and laboratory data.
Main Results:
- The study included 101 pediatric patients (female to male ratio 6.2:1) with a mean age of onset of 9.7 years.
- Common manifestations included renal (86.2%), skin/mucocutaneous (76.3%), and hematological (73.4%) involvement.
- Proteinuria, malar rash, and anemia were the most frequent findings, with Lupus nephritis WHO class IV being the most common renal biopsy finding. High rates of ANA (92%) and Anti-dsDNA (70.2%) positivity were observed.
Conclusions:
- The clinical and laboratory features of pediatric SLE at Siriraj Hospital are consistent with those reported in other regions.
- Early recognition and comprehensive management are vital for pediatric SLE patients.
- This study contributes valuable data on pediatric SLE in Thailand, aiding comparative research.
Abstract:
A descriptive study of one hundred and one pediatric patients with systemic lupus erythematosus treated between July 1985 and March 2003 in Department of Pediatrics, Faculty of Medicine Siriraj Hospital was conducted. According to existing database, there were a total of 181 patients, 101 of them (55.8%) had available data for review. The female to male ratio was 6.2:1. The mean and median ages of onset were 9.7 +/- 2.8 and 10 +/- 2.2 years, respectively (range 4-14 years). The clinical presentations were renal involvement in 87 patients (86.2%), skin and mucocutaneous involvement 77 patients (76.3%), hematological abnormalities 74 patients (73.4%), musculoskeletal involvement 32 patients (31.7%), prolongedfever 24 patients (23.8%), neuropsychiatric symptoms 21 patients (20.8%), gastrointestinal involvement 20 patients (19.8%), cardiac involvement 14 patients (13.9%), lymphadenopathy 13 patients (12.9%), and pulmonary involvement 7 patients (6.9%). The most common renal, skin and mucocutaneous, and hematological manifestations were proteinuria, malar rash, and anemia, respectively. Lupus nephritis with WHO class IV was the most common histopathological finding of the initial renal biopsies. The most common neuropsychiatric, gastrointestinal, cardiac, and pulmonary involvements were seizure, hepatomegaly, pericarditis, and pleuritis, respectively. Ninety-two percent of patients reported as having significant ANA positive results using rat liver tissue as a substrate. Sixty-six out of 94 patients (70.2%) had positive test result of Anti-dsDNA. In conclusion, the age at onset, clinical manifestations and laboratory investigation results of SLE in children at Siriraj Hospital are comparable to other studies in the Country and also to other Asian and Western studies.
