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In Vivo Assessment of Alveolar Macrophage Efferocytosis Following Ozone Exposure
Published on: October 22, 2019
[General reproductive toxicity assessment in mice exposed to low-level ozone]
Zhi-jun Zhou1, Zheng-shi Zhou, Bai-zheng Tang
1Department of Laboratory Animal, Central South University, Changsha, China.
Objective:
To explore the general reproductive toxicity in mice exposed to low-level ozone.
Methods:
Low-level (0.09 approximately 0.18 mg/m3) ozone was created by 15 W ultraviolet light. The mice in 3 experimental groups and a control group were fed in low-level ozone environment or normal environment, respectively, and then the mating experiment was conducted. The pregnancy rate and the weight variations of the female mice were observed. The weight of the live fetuses was observed, and the appearance, bone and internal organs were checked for malformation.
Results:
There were no significant differences in any indexes between the experimental groups and the control group.
Conclusion:
Low-level ozone created by 15 W ultraviolet light may not have reproductive toxicity in mice.
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