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Related Experiment Videos

Increased complement classical and mannan-binding lectin pathway activities in schizophrenia.

Karine R Mayilyan1, James N Arnold, Julia S Presanis

  • 1MRC Immunochemistry Unit, Biochemistry Department, Oxford University, Oxford, UK.

Neuroscience Letters
|July 25, 2006
PubMed
Summary
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Schizophrenia patients show increased MBL-MASP-2 complement activation, suggesting a role for the immune system in this mental disorder. This immune system alteration may contribute to schizophrenia pathogenesis.

Area of Science:

  • Immunology
  • Neuroscience
  • Genetics

Background:

  • Schizophrenia is a severe mental disorder affecting 1-1.5% globally.
  • Immunological factors, including infectious or autoimmune processes, are implicated in schizophrenia's development.
  • The complement system, a key part of innate immunity, plays roles in inflammation and pathogen defense.

Purpose of the Study:

  • To investigate the role of the complement system, specifically Mannan-binding lectin (MBL) and its associated proteases (MASP-1, MASP-2), in schizophrenia.
  • To compare complement system activity in schizophrenic patients versus healthy individuals.

Main Methods:

  • Sera from 45 schizophrenic patients and 62 healthy volunteers were analyzed.
  • Measurements included total complement activity (CH50), C4 activity (C4 CH50), MBL levels, and MASP-1 and MASP-2 activities.

Related Experiment Videos

  • Focus was on MBL-bound MASP-2 activity, reflecting MBL pathway activation.

    • Main Results:

    • No significant differences in MBL levels or MASP-1 activity were found between groups.
    • Schizophrenic patients exhibited significantly higher MBL-bound MASP-2 activity (P<0.01).
    • This correlated with increased total complement activity (CH50, P<0.02) and C4 activity (C4 CH50, P<0.02) in patients.

    Conclusions:

    • The findings suggest an overactive MBL-mediated complement pathway in schizophrenia.
    • Alterations in the complement system, particularly involving MBL and MASP-2, may be implicated in the pathogenesis of schizophrenia.
    • Further research into immune system involvement in schizophrenia is warranted.