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Ocular hypotensive activity of pirbuterol eye drops in rabbits
L Bonomi1, S Perfetti, R Bellucci
1Department of Ophthalmology, University of Verona, Italy.
Journal of Ocular Pharmacology
|January 1, 1991
Abstract:
The IOP-lowering effect of pirbuterol, a beta-2 adrenergic agonist, was studied in rabbits. In normotensive rabbits, pirbuterol 0.5% eye drops reduced IOP by 20-25%. In ocular hypertensive rabbits (by glucose 5% venous infusion), pirbuterol reduced IOP by 20% (0.1% concentration) to 40% (0.5% and 1% concentration). A slight decrease in the effect was noticed after seven days of treatment.