Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Anticancer activity of polyoxomolybdate.

H Yanagie1, A Ogata, S Mitsui

  • 1Department of Intellectual Property, Project of Cancer Metastasis Inhibition, Research Center for Advanced Science and Technology, The University of Tokyo, 4-6-1 Komaba, Meguro-ku, Tokyo 153-8904, Japan. yanagie@ip.rcast.u-tokyo.ac.jp

Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie
|July 25, 2006
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Research Note: Expression of IGF-1 and IGF-1 receptor proteins in skeletal muscle fiber types in chickens with hepatic fibrosis.

Poultry science·2022
Same author

Renal arteriolar hyalinosis, not intimal thickening in large arteries, is associated with cardiovascular events in people with biopsy-proven diabetic nephropathy.

Diabetic medicine : a journal of the British Diabetic Association·2020
Same author

Rare bowel emphysema with superior mesenteric artery syndrome after surgery.

Annals of the Royal College of Surgeons of England·2019
Same author

A case of porokeratosis ptychotropica: successful treatment with topical 5% imiquimod cream.

Clinical and experimental dermatology·2017
Same author

Particle size specific distribution of perfluoro alkyl substances in atmospheric particulate matter in Asian cities.

Environmental science. Processes & impacts·2017
Same author

Measurement of the centrality dependence of the charged-particle pseudorapidity distribution in proton-lead collisions at [Formula: see text] TeV with the ATLAS detector.

The European physical journal. C, Particles and fields·2017
Same journal

Wnt activation during epileptogenesis prevents pathological immature dentate granule cell morphological changes in animal models of unilateral and bilateral temporal lobe epilepsy.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie·2026
Same journal

Protective effects of ACF210, a dual GLP-1/APJ receptor agonist, against cardiovascular-kidney-metabolic syndrome induced by T2D.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie·2026
Same journal

Tumor microenvironment-mediated interactions between macrophages and cancer cells define immunoregulatory transcriptional programs.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie·2026
Same journal

Photocontrol of zebrafish behavior with a photoswitchable ligand of nicotinic acetylcholine receptors.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie·2026
Same journal

Corrigendum to "Ruyiping extract reduces lung metastasis in triple negative breast cancer by regulating macrophage polarization" [Biomed. Pharmacother. 141 (2021) 111883].

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie·2026
Same journal

Microfluidic human liver slices reveal antifibrotic effects of liraglutide via HSC deactivation and ECM remodeling.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie·2026
See all related articles

The polyoxomolybdate compound PM-8 demonstrates significant anticancer properties by suppressing tumor growth and inducing apoptosis in various cancer cell lines. This research highlights PM-8 as a promising novel agent for treating difficult-to-treat cancers.

Area of Science:

  • Inorganic Chemistry
  • Medicinal Chemistry
  • Oncology

Background:

  • Polyoxomolybdates are a class of metal oxide cluster anions with potential medical applications.
  • The compound [NH3Pri]6[Mo7O24].3H2O, designated as PM-8, is identified as a significant antitumoral polyoxomolybdate.

Purpose of the Study:

  • To investigate the anticancer activities of PM-8 against various tumor types.
  • To elucidate the mechanisms underlying PM-8's anti-tumor effects, including apoptosis induction.

Main Methods:

  • In vivo studies using tumor-bearing mice to assess tumor growth suppression.
  • In vitro cell culture experiments with AsPC-1 cells to evaluate cytotoxicity and apoptosis.
  • DNA fragmentation assays, Hoechst staining, and flow cytometry to confirm apoptosis.

Related Experiment Videos

Main Results:

  • PM-8 exhibited growth suppression against Co-4 (colon), MX-1 (breast), OAT (lung), and MKN-45 (gastric) human cancer models.
  • PM-8 dose-dependently inhibited AsPC-1 cell growth, inducing DNA ladder formation and fragmentation.
  • Flow cytometry revealed a significant increase in apoptotic cells (35% at 48h, 57% at 72h) upon PM-8 treatment.

Conclusions:

  • PM-8 demonstrates potent anti-tumor activity through the activation of apoptotic pathways.
  • Polyoxomolybdates, exemplified by PM-8, hold promise as novel therapeutic agents for challenging clinical cancers.