Related Experiment Video

Updated: Aug 7, 2026

Chemical Inactivation of the E3 Ubiquitin Ligase Cereblon by Pomalidomide-based Homo-PROTACs
10:44

Chemical Inactivation of the E3 Ubiquitin Ligase Cereblon by Pomalidomide-based Homo-PROTACs

Published on: May 15, 2019

Anticancer activity of polyoxomolybdate

H Yanagie1, A Ogata, S Mitsui

  • 1Department of Intellectual Property, Project of Cancer Metastasis Inhibition, Research Center for Advanced Science and Technology, The University of Tokyo, 4-6-1 Komaba, Meguro-ku, Tokyo 153-8904, Japan. yanagie@ip.rcast.u-tokyo.ac.jp

Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie
|July 25, 2006
PubMed

Insights

The polyoxomolybdate compound PM-8 demonstrates significant anticancer properties by suppressing tumor growth and inducing apoptosis in various cancer cell lines. This research highlights PM-8 as a promising novel agent for treating difficult-to-treat cancers.

Area of Science:

  • Inorganic Chemistry
  • Medicinal Chemistry
  • Oncology

Background:

  • Polyoxomolybdates are a class of metal oxide cluster anions with potential medical applications.
  • The compound [NH3Pri]6[Mo7O24].3H2O, designated as PM-8, is identified as a significant antitumoral polyoxomolybdate.

Purpose of the Study:

  • To investigate the anticancer activities of PM-8 against various tumor types.
  • To elucidate the mechanisms underlying PM-8's anti-tumor effects, including apoptosis induction.

Main Methods:

  • In vivo studies using tumor-bearing mice to assess tumor growth suppression.
  • In vitro cell culture experiments with AsPC-1 cells to evaluate cytotoxicity and apoptosis.
  • DNA fragmentation assays, Hoechst staining, and flow cytometry to confirm apoptosis.

Main Results:

  • PM-8 exhibited growth suppression against Co-4 (colon), MX-1 (breast), OAT (lung), and MKN-45 (gastric) human cancer models.
  • PM-8 dose-dependently inhibited AsPC-1 cell growth, inducing DNA ladder formation and fragmentation.
  • Flow cytometry revealed a significant increase in apoptotic cells (35% at 48h, 57% at 72h) upon PM-8 treatment.

Conclusions:

  • PM-8 demonstrates potent anti-tumor activity through the activation of apoptotic pathways.
  • Polyoxomolybdates, exemplified by PM-8, hold promise as novel therapeutic agents for challenging clinical cancers.

More Related Videos

Anticancer Metal Complexes: Synthesis and Cytotoxicity Evaluation by the MTT Assay11:14

Anticancer Metal Complexes: Synthesis and Cytotoxicity Evaluation by the MTT Assay

Published on: November 10, 2013

Preclinical Assessment of the Bioactivity of the Anticancer Coumarin OT48 by Spheroids, Colony Formation Assays, and Zebrafish Xenografts09:20

Preclinical Assessment of the Bioactivity of the Anticancer Coumarin OT48 by Spheroids, Colony Formation Assays, and Zebrafish Xenografts

Published on: June 26, 2018

Related Concept Videos

mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
Electron Transport Chain: Complex I and II01:46

Electron Transport Chain: Complex I and II

The mitochondrial electron transport chain (ETC) is the main energy generation system in the eukaryotic cells. However, mitochondria also produce cytotoxic reactive oxygen species (ROS) due to the large electron flow during oxidative phosphorylation. While Complex I is one of the primary sources of superoxide radicals, ROS production by Complex II is uncommon and may only be observed in cancer cells with mutated complexes.
ROS generation is regulated and maintained at moderate levels necessary...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Drugs that Stabilize Microtubules01:15

Drugs that Stabilize Microtubules

Microtubules are dynamic structures that undergo cycles of catastrophe and rescue. The microtubules play a central role in cell division by forming the spindle apparatus for segregating the chromosomes. This makes them ideal targets for regulating dividing cells in tumors and malignant cancer cells. Microtubule stabilizing drugs help stabilize the microtubule formation and promote its polymerization. Paclitaxel was the first microtubule stabilizing agent used as anticancer drug in chemotherapy...