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Tailoring In Vivo Cytotoxicity Assays to Study Immunodominance in Tumor-specific CD8+ T Cell Responses
Published on: May 6, 2019
Inflaming the CD8+ T cell response
Jodie S Haring1, Vladimir P Badovinac, John T Harty
1Department of Microbiology, University of Iowa, Iowa City, 52242, USA.
Abstract:
Although inflammatory cytokines induced by infection or vaccination with adjuvants have long been known to stimulate optimal antigen-presenting cell function, recent evidence indicates that some inflammatory cytokines also act directly on the responding T cells to control their response to infection. Here, we review the evidence that specific inflammatory cytokines act to control the magnitude of expansion, the degree of contraction, and the rate of memory cell development. These data may suggest new strategies for manipulating vaccine efficacy in the quest to protect against pathogenic microbes.
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