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Updated: Aug 7, 2026

Silencing of BRCA2 to Identify Novel BRCA2-regulated Biological Functions in Cultured Human Cells
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Aurora-A amplification associated with BRCA2 mutation in breast tumours

Sigridur K Bodvarsdottir1, Holmfridur Hilmarsdottir, Valgerdur Birgisdottir

  • 1Icelandic Cancer Society, Skogarhlid 8, 105 Reykjavik, Iceland; University of Iceland, Department of Medicine, Vatnsmyrarvegi 16, 101 Reykjavik, Iceland.

Cancer Letters
|July 25, 2006
PubMed
Summary

Aurora-A amplification is more common in breast tumors with BRCA2 mutations. This suggests that Aurora-A targeted therapy may be effective for BRCA2 or TP53 mutated breast cancers.

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