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Long-acting risperidone: focus on safety
1Department of Psychiatry, Ludwig-Maximilians-University, Munich, Germany. hans-juergen.moeller@med.uni-muenchen.de
Clinical Therapeutics
|July 25, 2006
Summary
Long-acting risperidone (LAR) is well-tolerated in patients with schizophrenia and schizoaffective disorder, showing low adverse event withdrawal rates and no increased risk compared to placebo when switching antipsychotics.
Area of Science:
- Psychiatry
- Pharmacology
- Clinical Therapeutics
Background:
- Atypical antipsychotics offer improved tolerability over conventional agents.
- Long-acting risperidone (LAR) is the first long-acting injectable atypical antipsychotic, effective for schizophrenia and schizoaffective disorder.
Purpose of the Study:
- To review clinical evidence on the tolerability of LAR.
- To assess LAR's utility in specific patient groups, including the elderly and younger individuals.
Main Methods:
- Searched MEDLINE and EMBASE (1994-2006) for studies on LAR tolerability.
- Included clinical studies reporting tolerability data for LAR.
- Reviewed conference abstracts and posters.
Main Results:
- LAR was generally well tolerated, with low withdrawal rates (1%-16%) when switching from other antipsychotics.
- Associated with minimal short-term weight gain (1-2 kg) and no negative impact on lipids or glucose.
- Elevated prolactin levels were infrequent (2%-7%), asymptomatic, and decreased over time.
Conclusions:
- LAR demonstrates good tolerability across patient groups, including the elderly and those with schizoaffective disorder.
- Switching to LAR from other antipsychotics did not increase adverse event risk compared to placebo.
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