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Effect of anoxia on in vitro bladder function.

Y Zhao¹, A J Wein, A Bilgen

¹Division of Urology, University of Pennsylvania School of Medicine, Philadelphia.

|January 1, 1991

Summary

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Anoxia significantly impairs bladder emptying and pressure generation, with emptying being more affected than pressure. This study investigated anoxia

Area of Science:

Urology
Physiology

Background:

Previous studies showed anoxia inhibits bethanechol-induced bladder emptying.
The selective effect of anoxia on receptor-mediated versus non-receptor-mediated stimulation was unclear.

Purpose of the Study:

To compare anoxia's effect on in vitro rabbit bladder pressure generation, pressure sustainment, and emptying.
To differentiate anoxic effects on receptor-mediated (bethanechol, field stimulation) and non-receptor-mediated contractile stimulation.

Main Methods:

In vitro whole bladder preparation from New Zealand white rabbits.
Bladders were subjected to anoxia (95% nitrogen, 5% CO2) and stimulated with field stimulation (FS), bethanechol, and KCl.
Effects on pressure generation, sustainment, and emptying were measured over time.

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Main Results:

Anoxia caused a time-dependent decrease in pressure generation rate, pressure magnitude, and volume emptied in response to FS and bethanechol.
Bladder emptying was significantly more inhibited by anoxia than pressure generation for both FS and bethanechol.

Conclusions:

Anoxia impairs both bladder pressure generation and emptying.
The inhibitory effect of anoxia is more pronounced on bladder emptying compared to pressure generation.