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Updated: Aug 7, 2026
Trichuris muris Infection: A Model of Type 2 Immunity and Inflammation in the Gut
Published on: May 24, 2011
Murine model of infection by Tropheryma whipplei
Séverine Genot1, Andreas Stein, Hubert Lepidi
1Unité des Rickettsies, CNRS UMR 6020, Faculté de Médecine, Université de la Méditerranée, 27 Bld. Jean Moulin, 13385 Marseille Cedex 05, France.
Abstract:
We developed an animal model reproducing several aspects of Whipple's disease. Immunocompetent mice were persistently infected with Tropheryma whipplei, its etiological agent, and developed liver granulomas. SCID mice were infected similarly but did not develop tissue lesions. The delayed clearance of T. whipplei suggests a protective role for innate immunity.
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