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Updated: Aug 7, 2026

Protective Efficacy and Pulmonary Immune Response Following Subcutaneous and Intranasal BCG Administration in Mice
Published on: September 19, 2016
Enhanced immunogenicity and protective efficacy with the use of interleukin-12-encapsulated microspheres plus AS01B
Sang-Jun Ha1, Su-Hyung Park, Hye-Ju Kim
1Division of Molecular and Life Sciences, Postech Biotech Center, Pohang University of Science & Technology, Hyoja-dong, Pohang, Korea.
Abstract:
Tuberculosis subunit vaccines codelivered with interleukin-12 (IL-12)-encapsulated microspheres (IL-12EM) are designed for a sustained release of IL-12 and could induce strong Th1 immune responses specific to Ag85A and ESAT-6. The adjuvant combination of IL-12EM plus AS01B was a more efficient way to induce a sustained Th1 immunity and protection against Mycobacterium tuberculosis.
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