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Using Mouse Oocytes to Assess Human Gene Function During Meiosis I
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Using Mouse Oocytes to Assess Human Gene Function During Meiosis I

Published on: April 10, 2018

PRINS as an efficient tool for aneuploidy assessment in human oocytes and preimplantation embryos

Franck Pellestor1, Brigitte Andréo, Tal Anahory

  • 1Institute of Human Genetics, CNRS UPR 1142, Montpellier, France.

Methods in Molecular Biology (Clifton, N.J.)
|July 25, 2006
PubMed

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Nondisjunction01:21

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Nondisjunction is the failure of homologous chromosomes or sister chromatids to separate correctly and move to the opposite poles of the cells. This produces daughter cells with abnormal chromosome numbers.  Nondisjunction is common during anaphase I or anaphase II of meiosis.  Mutations in synaptonemal complex proteins that attach homologous chromosomes increase the chances of nondisjunction in anaphase I of meiosis I. In contrast, mutations in topoisomerases and condensins that hold sister...